Table 1 Composition of Thymoquinone (THQ)-loaded-PLGA-nanoparticles
| Formulation code | PLGA (mg) | DCM (mL) | THQ (mg) | PVA (%) | Mean particle size (nm) ± SD | Polydispersity index (PDI) ± SD | Zeta potential | Entrapment efficiency (EE %) ± SD | Drug loading (DL %) ± SD | Process yield (%) ± SD |
|---|---|---|---|---|---|---|---|---|---|---|
| THQ-N1 | 100 | 8 | 10 | 1 | 97.36 ± 2.01 | 0.263 ± 0.004 | − 17.98 ± 1.09 | 82.49 ± 2.38 | 5.09 ± 0.13 | 88.94 ± 3.48 |
| THQ-N2 | 200 | 8 | 10 | 1 | 196.48 ± 2.37 | 0.371 ± 0.005 | − 21.31 ± 1.13 | 73.16 ± 2.16 | 5.10 ± 0.11 | 86.42 ± 3.08 |
| THQ-N3 | 300 | 8 | 10 | 1 | 297.16 ± 2.71 | 0.389 ± 0.005 | − 25.46 ± 1.30 | 70.94 ± 3.11 | 5.76 ± 0.12 | 83.017 ± 4.01 |
| THQ-N4 | 400 | 8 | 10 | 1 | 372.49 ± 3.23 | 0.410 ± 0.006 | − 28.61 ± 1.41 | 70.69 ± 3.21 | 6.33 ± 0.21 | 77.12 ± 3.14 |
| THQ-N5 | 500 | 8 | 10 | 1 | 411.96 ± 3.69 | 0.509 ± 0.006 | − 31.79 ± 1.59 | 68.75 ± 3.37 | 6.94 ± 0.48 | 72.03 ± 4.59 |